P049 AMINOSALYCILATES DO NOT AFFECT THIOPURINE-METHYL-TRANSFERASE (TPMT) ACTIVITY IN INFLAMMATORY BOWEL DISEASE (IBD)

Endoscopy in Paediatric Inflammatory Bowel Disease (IBD)

Thiopurine methyltransferase genotype and thiopurine S-methyltransferase activity in Greek children with inflammatory bowel disease

BACKGROUND Azathioprine (AZA) and 6-mercaptopurine (6MP) are used in the treatment of pediatric inflammatory bowel disease (IBD). Genetic variations in thiopurine S-methyltranfarase (TPMT) gene have been correlated with enzyme activity and with the occurrence of adverse events to AZA and 6MP. The aim of the present study was to examine the sensitivity and specificity of TPMT genotyping for TPMT...

Treatment of inflammatory bowel disease (IBD).

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract, which includes Crohn's disease (CD) and ulcerative colitis (UC). These diseases have become important health problems. Medical therapy for IBD has advanced dramatically in the last decade with the introduction of targeted biologic therapies, the optimization of older therapies, including rugs such ...

Digestive System Inflammatory Bowel Disease (IBD)

Inflammatory bowel disease is an immune related disorder in which the intestines are chronically or intermittently inflamed. A synonym for inflammatory bowel disease that is abbreviated the same way is ‘irritable bowel disease’. Affected dogs may be presented with a history of vomiting, diarrhea, weight loss or a combination of these signs. There is a great deal of variation in the severity, du...

The effect of allopurinol and low-dose thiopurine combination therapy on the activity of three pivotal thiopurine metabolizing enzymes: results from a prospective pharmacological study.

INTRODUCTION Thiopurine therapy is often discontinued in inflammatory bowel disease (IBD) patients. The xanthine oxidase (XO) inhibitor allopurinol has previously shown to enhance thiopurine efficacy and to prevent adverse reactions, the mechanism of this beneficial interaction is not completely clarified. The aim of this study is to observe possible effects of allopurinol and low-dose thiopuri...